The aim of the course is to make the interested student knowledgeable in the basic notions of the Theory of Distributions and its use in concrete applications. Typically, a person working in the field of Electronic Engineering, will be able to apply the tools learned in the course, to address problems coming from Signal Theory. The final chapter of the course can also be seen as an introduction to Partial Differential Equations, paving therefore the way to further mathematical studies for interested people. Finally, the Theory of Distributions is a beautiful piece of Mathematics, and the course is surely a good opportunity also for all those persons who are simply interested in broadening their mathematical knowledge, without an immediate practical aim.